Mucins are a family of highly glycosylated, large molecular weight glycoproteins which are associated with many epithelial cells. MUC2 is the major intestinal mucin. O-glycans are attached to MUC2 in a potentially diverse arrangement, which is crucial for their interaction with endogenous and exogenous lectins.
| Inventor | Institute |
|---|---|
| Lindy Durrant | University of Nottingham |
| Cat. #: | 151307 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Colorectal cancer |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction |
| Application: | IHC ; ELISA ; IHC |
| Target: | Mucin2 (MUC2) |
| Reactivity: | Human |
| Clone: | 994/152 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Mucins are a family of highly glycosylated, large molecular weight glycoproteins which are associated with many epithelial cells. MUC2 is the major intestinal mucin. O-glycans are attached to MUC2 in a potentially diverse arrangement, which is crucial for their interaction with endogenous and exogenous lectins. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | A peptide based on the tandem repeat sequence of MUC2 |
| Myeloma used: | NS0 |
| Target background: | Mucins are a family of highly glycosylated, large molecular weight glycoproteins which are associated with many epithelial cells. MUC2 is the major intestinal mucin. O-glycans are attached to MUC2 in a potentially diverse arrangement, which is crucial for their interaction with endogenous and exogenous lectins. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Gold et al. 2013. Mol Cancer. 12(1):143. PMID: 24257318. Mapping PAM4 (clivatuzumab), a monoclonal antibody in clinical trials for early detection and therapy of pancreatic ductal adenocarcinoma, to MUC5AC mucin. Durrant et al. 1994. Eur J Cancer. 30A(3):355-63. PMID: 8204359. Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin. |
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