Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple […]
| Inventor | Institute |
|---|---|
| Birgit Lane | Queen Mary University of London |
| Cat. #: | 151127 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | FACS ; IHC ; IF ; WB |
| Target: | Keratin 7 |
| Reactivity: | Human |
| Clone: | LP5K |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair roo… |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Molecular weight: | 54 kDa |
| Immunogen: | Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair roo… |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515 Sato et al. 2005. Blood. 106(2):428-35. PMID: 15797992. Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries. Sato et al. 2003. Development. 130(22):5519-32. PMID: 14530297. Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype. Markey … |
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