Glial fibrillary acidic protein, or GFAP, is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins.
| Inventor | Institute |
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| John Kemshead | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 152989 |
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| Product description: | Glial fibrillary acidic protein, or GFAP, is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. |
| Alternate name: | wu:fb34h11, ALXDRD, cb345, etID36982.3, FLJ42474, FLJ45472, GFAP, GFAP_HUMAN, gfapl, Glial fibrillary acidic protein, Intermediate filament protein, wu:fk42c12, xx:af56734, zgc:11485 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 50 kDa |
| Immunogen: | Relatively benign cerebellar astrocytoma from 5 year old child. |
| Myeloma used: | P3X63Ag8 |
| Cat. #: | 152989 |
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| Provenance and Ownership: | The Anti-GFAP [FD19-9] mAb is owned by Cancer Research UK. CancerTools supplies the Anti-GFAP [FD19-9] mAb under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-GFAP [FD19-9] mAb directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Cell signaling and signal transduction; Neurobiology; Stem cell biology |
| Application: | IHC ; IF |
| Target: | Glial fibrillary acid protein |
| Reactivity: | Human |
| Clone: | FD19-9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Glial fibrillary acidic protein, or GFAP, is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461. Isolation and characterization of human gastric cell lines with stem cell phenotypes. Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008. High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments. Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990. Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid. Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983 |
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