Anti-FANCM [M40-P2C6]

Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA.

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
SKU: 151876
Product description: Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.
Alternate name: Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 25 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP25
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Peptide Sequence – MLPNDLNQDR (amino acids 2069 -2078)
Myeloma used: P3X63Ag8.653
Cat. #: 151876
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics
Application: ELISA ; IF ; WB
Target: Fanconi Anemia, Complementation Group M (FANC-M)
Reactivity: Human
Clone: M40-P2C6
Host: Mouse
Class: Monoclonal
Target background: Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

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