CEP164 plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells.
| Inventor | Institute |
|---|---|
| Ciaran Morrison | National University of Ireland, Galway; Centre For Chromosome Biology |
| Cat. #: | 153780 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Metabolism |
| Application: | IHC ; IF ; IP ; WB |
| Target: | Anti-CEP164 [1F3G10] |
| Reactivity: | Human |
| Clone: | [1F3G10] |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Centrosomal protein of 164 kDa, KIAA152, NPHP15 |
|---|---|
| Product description: | CEP164 plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 164 kDa (runs c.190) |
| Immunogen: | Recombinant human CEP164 amino acids 6-296 (bacterially expressed from pGEX4T as a GST fusion, then thrombin-cleaved and purified). |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | CEP164 plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Flynn et al. 2020. Hum Mol Genet. 29(3):407-417. PMID: 31868218. Khouj et al. 2019. J Cell Sci. 132(19):. PMID: 31492759. Ogungbenro et al. 2018. J Cell Biol. 217(4):1205-1215. PMID: 29440264. Sieben et al. 2018. Nat Methods. 15(10):777-780. PMID: 30275574. Daly et al. 2016. J Cell Sci. 129(9):1769-74. PMID: 26966185. |
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