A broadly distributed receptor. Variants of CD44 are associated with metastasis.
| Inventor | Institute |
|---|---|
| Roy Jefferis | University of Birmingham |
| SKU: | 151434 |
|---|---|
| Product description: | A broadly distributed receptor. Variants of CD44 are associated with metastasis. |
| Alternate name: | CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP9 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Hiatt myeloma cells |
| Myeloma used: | NS0 |
| Cat. #: | 151434 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IHC ; IF ; IP ; WB |
| Target: | CD44 |
| Reactivity: | Human |
| Clone: | BU52 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | A broadly distributed receptor. Variants of CD44 are associated with metastasis. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Knapp W. et al. 1989. Leukocyte Typing IV Oxford University Press Brown et al. 2005. Exp Cell Res. 303(2):400-14. PMID: 15652352. Regulation of hyaluronan binding by F-actin and colocalization of CD44 and phosphorylated ezrin/radixin/moesin (ERM) proteins in myeloid cells. Takahashi et al. 2003. Lung Cancer. 41(2):145-53. PMID: 12871777. Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicity. Okamoto et al. 1999. J Biol Chem. 274(36):25525-34. PMID: 10464284. Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins. Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568. Prolonged phenotypic, Fn, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand. Guo et al. 1994. Int Immunol. 6(2):213-21. PMID: 7512372. Palmitoylation of CD44 interferes with CD3-mediated signaling in human T lymphocytes. Lesley et al. 1993. Adv Immunol. 54:271-335. PMID: 8379464. CD44 and its interaction with extracellular matrix. Anstee et al. 1991. Immunology. 74(2):197-205. PMID: 1721039. New monoclonal antibodies in CD44 and CD58: their use to quantify CD44 and CD58 on normal human erythrocytes and to compare the distribution of CD44 and CD58 in human tissues. |
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