SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias.
| Inventor | Institute |
|---|---|
| Karen Pulford | University of Oxford |
| SKU: | 151664 |
|---|---|
| Product description: | SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias. |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Immunogen: | Hairy cell leukaemia cells |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151664 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology |
| Application: | IHC |
| Target: | CD22 |
| Reactivity: | Human |
| Clone: | 4KB71 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Mason et al. 1987. Blood. 69(3):836-40. PMID: 3101766. Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells. |
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