Anti-BORIS [20B11] mAb

Reagent for research, diagnostic tool. BORIS protein has been identified as Cancer-Testis Antigen (CTA) with testis-specific paralogue of the CCCTC-binding factor. Recent studies have demonstrated that d BORIS is directly responsible for the transcriptional activation of TSP50 (testes-specific protease 50).

Contributors

Inventor Institute
Elena Klenova University of Essex
SKU: 152812
Product description: Reagent for research, diagnostic tool. BORIS protein has been identified as Cancer-Testis Antigen (CTA) with testis-specific paralogue of the CCCTC-binding factor. Recent studies have demonstrated that d BORIS is directly responsible for the transcriptional activation of TSP50 (testes-specific protease 50).
Alternate name: Brother of the regulator of imprinted sites, Cancer/testis antigen 27, CCCTC binding factor (zinc finger protein) like, CCCTC-binding factor, CT27, CTCF paralog, CTCF T, CTCF-like protein, Ctcfl, CTCFL_HUMAN, dJ579F2.2, HMG 1L1, HMGB1L1, MGC163358, MGC16915, MGC16916
Conjugation: Unconjugated
Isotype: IgG3 kappa
Molecular weight: 83 kDa
Immunogen: Synthetic peptide within the BORIS C-terminal domain (aa 614-648) (CG)GEMFPVACRETTARVKEE (NB – the first two aa do not belong to BORIS)
Cat. #: 152812
Provenance and Ownership: The Anti-BORIS [20B11] mAb is owned by Cancer Research UK. CancerTools supplies the Anti-BORIS [20B11] mAb under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-BORIS [20B11] mAb directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Genetics
Application: ChIP ; ELISA ; IHC ; IF ; IP ; WB
Target: BORIS
Reactivity: Human
Clone: 20B11
Host: Mouse
Class: Monoclonal
Target background: BORIS protein has been identified as Cancer-Testis Antigen (CTA) with testis-specific paralogue of the CCCTC-binding factor. Recent studies have demonstrated that d BORIS is directly responsible for the transcriptional activation of TSP50 (testes-specific protease 50).
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Debruyne et al. 2019. Nature. 572(7771):676-680. PMID: 31391581.

Images

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Monoclonal anti- BORIS C-terminal antibody from clone 20B11 specifically recognises the C terminal domain of BORIS; and the endogenous and exogenous BORIS protein. Cell lysates were resolved by SDS-PAGE; blotted and probed with the original mouse supernatant of the 20B11 clone. Positions of BORIS and the C-terminal domain of BORIS are indicated. B; bacterially expressed BORIS; *; 293T cells transfected with 0.5?g of the plasmid expressing BORIS; M; Molecular marker.

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