Anti-Bam32 [4H9]

B lymphocyte-associated adaptor protein (Bam32) is 32 kDa and is expressed in high levels in the germinal center (GC) of B cells. It consists of a src homology 2 (SH2) domain at the NH2 terminal which binds phospholipase C (PLC) gamma 2 and a pleckstrin homology (PH) domain at the COOH-terminal. Bam32 acts as an adaptor that integrates protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K) necessary for signaling in B cells. Bam32 is recruited to the plasma membrane upon B cell receptor (BCR) ligation. BCR ligation induces colocalization of Bam32 with lipid rafts, clathrin, and actin filaments. BCR internalization…

Contributors

Institute
A*STAR Accelerate Technologies Pte Ltd
SKU: 152634
Product description: B lymphocyte-associated adaptor protein (Bam32) is 32 kDa and is expressed in high levels in the germinal center (GC) of B cells. It consists of a src homology 2 (SH2) domain at the NH2 terminal which binds phospholipase C (PLC) gamma 2 and a pleckstrin homology (PH) domain at the COOH-terminal. Bam32 acts as an adaptor that integrates protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K) necessary for signaling in B cells. Bam32 is recruited to the plasma membrane upon B cel…
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: GST-Bam32 fusion protein
Myeloma used: Sp2/0-Ag14
Cat. #: 152634
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction;Immunology
Application: WB
Target: B lymphocyte-associated adaptor protein
Reactivity: Human
Clone: 4H9
Host: Mouse
Class: Monoclonal
Target background: B lymphocyte-associated adaptor protein (Bam32) is 32 kDa and is expressed in high levels in the germinal center (GC) of B cells. It consists of a src homology 2 (SH2) domain at the NH2 terminal which binds phospholipase C (PLC) gamma 2 and a pleckstrin homology (PH) domain at the COOH-terminal. Bam32 acts as an adaptor that integrates protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K) necessary for signaling in B cells. Bam32 is recruited to the plasma membrane upon B cel…
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

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Western blot analysis of a A20 cell lysate using anti-Bam32 [4H9]

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