Anti-APC5 [APC5#4]

APC5 is a component of the anaphase-promoting complex/cyclosome (APC) that regulates cell cycle progression through mitosis and G1. APC5 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. The APC is inactivated by protein kinase A and is activated by CDC20 and Cdh1.

Contributors

Inventor Institute
Andy Turnell University of Birmingham
SKU: 151567
Product description: APC5 is a component of the anaphase-promoting complex/cyclosome (APC) that regulates cell cycle progression through mitosis and G1. APC5 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. The APC is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
Alternate name: Anaphase-promoting complex subunit 5; RMC1; YOR249C
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: GST-human APC5
Myeloma used: Sp2/0-Ag14
Cat. #: 151567
Provenance and Ownership: The Anti-APC5 [APC5#4] is owned by Cancer Research UK. CancerTools supplies the Anti-APC5 [APC5#4] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-APC5 [APC5#4] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Biochemistry;Cell biology
Application: IF ; IP ; WB
Target: Anaphase-promoting complex subunit 5 (APC5)
Reactivity: Human
Clone: APC5#4
Host: Mouse
Class: Monoclonal
Target background: APC5 is a component of the anaphase-promoting complex/cyclosome (APC) that regulates cell cycle progression through mitosis and G1. APC5 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. The APC is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Turnell et al. 2005. Nature. 438(7068):690-5. PMID: 16319895.

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.

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