Anti-ADA [ADA-1]

Ada is an O6-methylguanine DNA methyltransferase that protects against DNA alkylation by the repair of methylated bases. Ada also functions as a positive regulator of the adaptive response to DNA alkylation damage. Induction of the Ada protein is a sign of environmentally caused mutagenesis in bacteria.

Contributors

Inventor Institute
Julian Gannon Cancer Research UK, London Research Institute: Clare Hall Laboratories
SKU: 151072
Product description: Ada is an O6-methylguanine DNA methyltransferase that protects against DNA alkylation by the repair of methylated bases. Ada also functions as a positive regulator of the adaptive response to DNA alkylation damage. Induction of the Ada protein is a sign of environmentally caused mutagenesis in bacteria.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: ADA protein
Myeloma used: Sp2/0-Ag14
Cat. #: 151072
Provenance and Ownership: The Anti-ADA [ADA-1] is owned by Cancer Research UK. CancerTools supplies the Anti-ADA [ADA-1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-ADA [ADA-1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Microbiology;Cancer;Genetics;Metabolism
Application: WB ; IHC ; IP ; RIA ; WB
Target: ADA protein
Reactivity: E.coli
Clone: ADA-1
Host: Mouse
Class: Monoclonal
Target background: Ada is an O6-methylguanine DNA methyltransferase that protects against DNA alkylation by the repair of methylated bases. Ada also functions as a positive regulator of the adaptive response to DNA alkylation damage. Induction of the Ada protein is a sign of environmentally caused mutagenesis in bacteria.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

McCormack et al. 2015. Elife. 4:. PMID: 26402460.

Vaughan et al. 1991. Carcinogenesis. 12(2):263-8. PMID: 1995192.

Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli.

Images

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Adapted from McCormack et al. 2015. Elife. 4. PMID

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