Showing results for tumour immunology

Tumour Antigens Blog Post is committed to empower cancer researchers and the advancement of novel discoveries in tumour immunology by providing relevant research tools, including antibodies targeting tumour antigens. Image: Human breast cancer stained with an antibody to Pax-2. Photo credit: Jason Carroll at the CRI. Tumour antigens are proteins, glycoproteins, glycolipids, or carbohydrates found in tumour cells and recognised by cellular or humoral effectors of the immune system. Tumour antigens are not only useful in identifying cancer cells, they also can be leveraged as targets in cancer therapy. With the ever-increasing potential of tumour antigens in immunotherapy approaches, including cell therapy and cancer vaccines, their discovery and research has become crucial to support successful immunotherapy. Tumour antigens can be classified into tumour-specific antigens and tumour-associated antigens, which in turn can be sub-categorised, based on antigen origin (1,2). Tumour-specific antigens are restricted to tumours and are not found in healthy cells as they are the result of malignant mutations or the expression of viral elements (1,2). They include: > Neoantigens, produced as a direct consequence of genetic alteration caused by tumour DNA mutations and are […]

Tumour Immunology Antibodies Page

Tumour immunology studies the complex interactions between cancer cells and the immune system. Research in this field aims to uncover the mechanisms by which the immune system inhibits cancer growth […]

Introducing the pcPPT-mPGK-attR-sLPmCherry-WPRE vector Blog Post

One of the major challenges for tumour research is identifying how tumour cells exploit their surrounding cells, the so-called tumour microenvironment (TME), to help form and expand the tumour itself. […]

Anti-HIF1A [Ha111a] Product

[…] microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.

MB49 Cell Line in culture - sub confluence (A)

MB49 Cell Line Product

[…] transformed by chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) in culture. It is one of the most-established murine tumour cell line to study human bladder cancer, widely used by scientists for more than […]

Targeting the difficult-to-drug protein – MYC Blog Post

[…] of cancer and distinct subtypes have been identified. Adding to the challenging complexities of cancer, is tumour heterogeneity, which refers to the differences among tumours of the same type within different […]

Cell staining with SMP14 hybridoma supernatant of MCF7 treated with Nutlin

Anti-MDM2 [SMP14] Product

MDM2 is over-expressed in many tumours. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein.

Anti-p53 [DO-11] Product

Anti-p53 DO-11 antibody recognises the human cellular tumour antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein upregulated […]

Anti-p53 [DO-12] Product

Anti-p53 DO-12 antibody recognises the human cellular tumour antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid (approx. 53kDa) cytoplasmic/ nuclear protein […]