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#151570

Anti-POT1 [MTA40]

Cat. #151570

Anti-POT1 [MTA40]

Cat. #: 151570

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: POT1

Class: Polyclonal

Application: IP ; WB

Reactivity: Human ; Mouse

Host: Rabbit

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Madalena Tarsounas

Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-POT1 [MTA40]
  • Research fields: Cancer;Genetics
  • Clone: MTA40
  • Tool sub type: Primary antibody
  • Class: Polyclonal
  • Conjugation: Unconjugated
  • Molecular weight: 70 kDa
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Application: IP ; WB
  • Description: POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.
  • Immunogen: Full-length human POT1 protein
  • Recommended controls: U2OS cells

Target Details

  • Target: POT1
  • Molecular weight: 70 kDa
  • Tissue cell line specificity: U2OS cells
  • Target background: POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.

Applications

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1.5 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS, 0.1% NaN3
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Dry ice

References

  • Martinez et al. 2010. Nat Cell Biol. 12(8):768-80. PMID: 20622869.
  • Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
  • Martnez et al. 2009. Genes Dev. 23(17):2060-75. PMID: 19679647.
  • Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

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