#160643

Anti-ORF45 [8B8]

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Cat. #160643

Anti-ORF45 [8B8]

Cat. #: 160643

Sub-type: Primary antibody

Unit size: 100 ug

Target: Open Reading Frame 45 clone [8B8]

Class: Monoclonal

Application: IP

Reactivity: Other Species

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Fanxiu Zhu

Institute: Florida State University Research Foundation

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-ORF45 [8B8]
  • Research fields: Genetics;Microbiology
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Other Species
  • Host: Mouse
  • Application: IP
  • Description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen. This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification.
  • Immunogen: A baculovirus-synthesized ORF45 was used as an antigen
  • Isotype: IgG

Target Details

  • Target: Open Reading Frame 45 clone [8B8]
  • Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015).ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen.This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification.

Applications

  • Application: IP

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Fu et al. 2015. J Virol. 89(1):195-207. PMID: 25320298.