Anti-HRX [HRX107]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-HRX [HRX107]
• Research fields: Cancer;Genetics
• Clone: HRX107
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: ChIP ; IHC ; IF ; WB
• Description: The HRX gene (also called MLL, ALL-1 or Htrx) located to chromosome band 11q23 is associated with specific subsets of acute Lukaemia through translocations that that result in its fusion with a variety of heterologous partners
• Immunogen: Synthetic peptides corresponding to 839-854 of the HRX protein
• Isotype: IgM
• Myeloma used: P3/NS1/1-Ag4.1

Target Details

• Target: Histone-lysine N-methyltransferase (HRX, MLL, ALL1, Htrx)
• Target background: The HRX gene (also called MLL, ALL-1 or Htrx) located to chromosome band 11q23 is associated with specific subsets of acute Lukaemia through translocations that that result in its fusion with a variety of heterologous partners

Applications

• Application: ChIP ; IHC ; IF ; WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Mueller et al. 2009. PLoS Biol. 7(11):e1000249. PMID: 19956800.
• Misguided transcriptional elongation causes mixed lineage leukemia.
• Butler et al. 1997. Blood. 89(9):3361-70. PMID: 9129043.
• The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures.