Anti-FOXP1 [JC12]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-FOXP1 [JC12]
• Clone: JC12
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Mouse
• Host: Mouse
• Application: WB ; ChIP ; IHC
• Description: JC12 has been used in the identification of a novel winged helix transcription factor, FOXP1.
• Isotype: IgG2a

Target Details

• Target: FOXP1
• Target background: The FOXP1 gene has been mapped to chromosome 3p14.1, a chromosomal locus shown to be disrupted in a range of solid tumors. Characterization of both FOXP1 mRNA and protein expression has shown that this molecule is widely expressed in normal tissues, and that its expression is frequently altered in solid tumors.

Applications

• Application: WB ; ChIP ; IHC

Handling

• Format: Liquid
• Concentration: 1mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: '-15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D.
• Gascoyne et al. 2016. Endocrinology. :en20161802. PMID: 28001444.
• Gascoyne et al. 2016. Leuk Lymphoma. :1-15. PMID: 27678023.
• The significance of FOXP1 in diffuse large B-cell lymphoma.
• FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.
• Wong et al. 2016. Oncotarget. :. PMID: 27224915.
• Brown et al. 2015. Leukemia. :. PMID: 26500140.
• FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
• Banham et al. 2001. Cancer Res. 61(24):8820-9. PMID: 11751404.
• The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.