Cat. #155241
Anti-CD45 [C363.16A]
Cat. #: 155241
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: CD45
Class: Monoclonal
Application: FACS ; IF ; IP ; WB
Reactivity: Mouse
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Yale University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD45 [C363.16A]
- Alternate name: YCD45R-1
- Research fields: Immunology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 190 kDa and 220 kDa
- Reactivity: Mouse
- Host: Rat
- Application: FACS ; IF ; IP ; WB
- Description: Monoclonal antibody directed against CD45RB isoform of CD45. Background and Research Application CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, na?ve T cells, thymocytes, weakly on macrophages, and dendritic cells. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. It plays a criti...
- Immunogen: cloned T cell lines belonging to the helper T cell (Th2) subset, final boost was given with helper/Th2 clone D10
- Immunogen uniprot id: P08575
- Isotype: IgG
Target Details
- Target: CD45
- Molecular weight: 190 kDa and 220 kDa
- Target background: Monoclonal antibody directed against CD45RB isoform of CD45. Background and Research Application CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, nave T cells, thymocytes, weakly on macrophages, and dendritic cells. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. It plays a cr...
Applications
- Application: FACS ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
References
- Shao et al. 2020. J Immunol. 204(1):37-48. PMID: 31757864.
- Garo et al. 2019. Cell Rep. 28(13):3353-3366.e5. PMID: 31553906.
- Timilshina et al. 2019. Cell Rep. 27(10):2948-2961.e7. PMID: 31167140.
- Imbratta et al. 2019. Sci Rep. 9(1):6135. PMID: 30992496.
- Lyons et al. 2018. PLoS Biol. 16(3):e2002417. PMID: 29596476.
- Lyons et al. 2018. Sci Signal. 11(519):. PMID: 29487189.
- Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241.
