Cat. #162374
Anti-Bop1 monoclonal antibody [BOP 6H11]
Cat. #: 162374
Sub-type: Primary antibody
Target: Human Block of Proliferation 1 (BOP1)
Class: Monoclonal
Application: WB
Reactivity: Human
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Helmholtz Munich Core Facility Monoclonal Antibodies
Primary Citation: Holzel et al. 2005. J. Cell Biol. 170: 367-378. PMID: 16043514
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Bop1 monoclonal antibody [BOP 6H11]
- Alternate name: Anti human Bop1 (block of proliferation) monoclonal antibody (clone BOP 6H11)
- Cancer type filter: Colorectal cancer
- Cancers detailed: Colorectal
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction
- Clone: BOP 6H11
- Tool type ecom: Antibody
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Rat
- Disease: Cancer
- Application: WB
- Description: Antibody for BOP1 (aka Blocking Protein 1 or BOP1 ribosomal biogenesis factor), a protein encoded by the BOP1 gene. It is involved in regulation of cell cycle, signal transduction by p53 class mediator, and ribosomal large subunit biogenesis. BOP1 has also been implicated in several cancer types including colorectal cancer where overexpression is associated with a poor patient prognosis.
- Immunogen: Ovalbumin coupled to SRGAGRTAAPSVRPEK peptide
- Isotype: IgG1, k
Target Details
- Target: Human Block of Proliferation 1 (BOP1)
- Target alternate names: Ribosome Biogenesis Protein BOP1
- Target background: Ribosome biogenesis protein BOP1 is a component of PeBoW that is involved in ribosome biogenesis and cell proliferation. Changes in Bop1 protein level affect the assembly and integrity of PeBoW (Pes1, Bop1, and WDR12) complex. Overexpression of Bop1 mRNA is associated with the development of colorectal cancer.
Applications
- Application: WB
References
- Holzel et al. 2005. J. Cell Biol. 170: 367-378. PMID: 16043514
