Tumour Antigens Blog Post

CancerTools.org is committed to empower cancer researchers and the advancement of novel discoveries in tumour immunology by providing relevant research tools, including antibodies targeting tumour antigens. Image: Human breast cancer stained with an antibody to Pax-2. Photo credit: Jason Carroll at the CRI. Tumour antigens are proteins, glycoproteins, glycolipids, or carbohydrates found in tumour cells and recognised by cellular or humoral effectors of the immune system. Tumour antigens are not only useful in identifying cancer cells, they also can be leveraged as targets in cancer therapy. With the ever-increasing potential of tumour antigens in immunotherapy approaches, including cell therapy and cancer vaccines, their discovery and research has become crucial to support successful immunotherapy. Tumour antigens can be classified into tumour-specific antigens and tumour-associated antigens, which in turn can be sub-categorised, based on antigen origin (1,2). Tumour-specific antigens are restricted to tumours and are not found in healthy cells as they are the result of malignant mutations or the expression of viral elements (1,2). They include: > Neoantigens, produced as a direct consequence of genetic alteration caused by tumour DNA mutations and are […]

Anti-PD-L1 [29E.2A3] Product

[…] specimens from patients with renal cell carcinoma found that high tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death. Many PD-L1 inhibitors […]

Adapted from Kannan et al. 2017. Sci Rep; 7

Anti-HPV16E7 [TVG 701Y] mAb Product

HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively.

Breast cancer Page

[…] of key biological processes in the tumour microenvironment, e.g. angiogenesis, tumour evasion, invasion, and migration. Tumour associated antigens Tumour associated antigens, e.g., MUC1 which is aberrantly overexpressed in 90% of human breast […]

Anti-HHV-8 LNA-1 [LN53] Product

Rat monoclonal antibody which targets human KSHV/HHV8 and simian RFHV Orf73 latency-associated nuclear antigen (LANA or LNA) with high specificity.

Anti-LRAT [M34-P1F10] Product

LRAT is significantly overexpressed in colorectal cancer and significantly associated with prognosis.

Anti-CEACAM5 (CD66e) [3E10-3] Product

CEACAM5 is a glycoprotein involved in cell adhesion and intracellular signaling. It is normally produced during fetal development in the gut, and its production stops before birth. CEA is re-expressed…

Anti-CXCL16 [4.4] Product

[…] be produced by constitutive cleavage from the cell membrane. In addition, CXCL16 expression has been associated with a number of human inflammatory diseases including rheumatoid arthritis, interstitial lung diseases, atherosclerosis, […]

Anti-PD-1 [J110] Product

The PD-1 protein is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.